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Protein Interaction Property Similarity Analysis

Demonstration Part 3:

Example demonstrating a PIPSA analysis using multiple templates to account for the effect of conformational variability.

Part 2 demonstrate a use of webPIPSA to analyze the relatedness of electrostatic potentials for one template structure. One can run the same analysis and select a template with a different conformation, to see if there are differences in similarity. This can now be achieved automatically by selecting multiple structural templates. Each sequence is then modelled against all templates and compared against each other. The result is not only a comparision of the different conformations, but also how similar the two conformations are.

Please note that selecting multiple templates will significantly increase the calculation time (scaales as N2).

Demonstration for P60174 (TPIS_HUMAN), step by step